![]() Because the results of the phase 4 studies are the proper criteria for how the vaccine works in the real world. However, in order to prove the effectiveness of the vaccine in terms of safety and side effects, the implementation of phase 4 of clinical studies is necessary. As of November 2021, 11 candidate vaccines for COVID-19 have been approved by the World Health Organization for mass vaccination after leaving phase 3 of clinical studies. In vaccines containing inactive or protein viruses, virus particles and proteins, as antigens, trigger the immune system. These viral proteins are eventually identified as antigens and stimulate antibody production. In nucleic acid and adenovirus-based vaccines, fragments of the virus mRNA or genome enter human cells and induce the production of viral proteins. There are four major strategies for producing COVID-19 vaccines, including nucleic acid-based vaccine (DNA–mRNA), viral vector (replication–non-replication), live inactivated (or attenuated) virus, and protein (spike protein or its subunits). ![]() Also, approximately 68.2% of the world's population has been fully vaccinated against this disease. In early 2021, the first vaccines were introduced to stop the pandemic. As of November 2022, 630.3 million people have been diagnosed with COVID-19 and 6.58 million deaths worldwide, according to WHO figures. This virus is known to cause widespread lung infection and hypoxia. Following that situation in 2020, the World Health Organization had to declare a global health emergency. A virus that was much more contagious than SARS Covid-1 and spread to different parts of the world in a short time. In December 2019, the SARS Covid-2 virus was introduced to the world. Herein, we have provided a comprehensive review of documents reporting neurological side effects of COVID-19 vaccines in international databases from 2020 to 2022 and discussed neurological disorders possibly caused by vaccination. These effects are often acute and transient, but they can be severe and even fatal in a few cases. ![]() The most important and common complications are cerebrovascular disorders including cerebral venous sinus thrombosis, transient ischemic attack, intracerebral hemorrhage, ischemic stroke, and demyelinating disorders including transverse myelitis, first manifestation of MS, and neuromyelitis optica. According to these reports, vaccination can have an adverse event, especially on nervous system. At the same time, there are many reports of side effects after getting a COVID-19 vaccine. Following the COVID-19 virus epidemic, extensive, coordinated international research has led to the rapid development of effective vaccines. Although vaccines are now considered the best way to achieve collective safety and control mortality, due to the critical situation, these vaccines have been issued the emergency use licenses and some of their potential subsequence side effects have been overlooked.
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In June 2015, Pornhub announced that it was going to make a pornographic film featuring real-life sex in space, named Sexplorations. Īs of 2009, three of the largest pornographic sites "RedTube, YouPorn and PornHub-collectively make up 100 million unique visitors". David Holmes of PandoDaily noted that Pornhub's data-intensive approach to playlists set it apart from previous attempts at user-generated playlists, and marked a new trend in the switch from content searching to passive curation among Web 2.0 websites. ![]() Pornhub also launched a content curation website on 9 October 2013 called "PornIQ", which uses an algorithm to create personalized video playlists for the viewer based on a number of factors, including their porn preferences, the time of day they're visiting the website, what part of the world they live in and the amount of time the viewer has to watch the video(s). In an effort to introduce quality curation to the site, the company launched a service called "Pornhub Select" in October 2013. Videos can be flagged if they contain content which violates the website's terms of service. Users may also optionally register a free Pornhub account, which additionally allows them to post comments, download videos and add videos to their favourites, as well as upload videos themselves. Users can share videos on social media websites and leave "like" or "dislike" votes. The website allows visitors to view pornographic videos from a number of categories, including professional and amateur pornography. Though not the most popular pornographic website, Pornhub is the single largest such website on the internet, hosting more videos than any similar site. As part of MindGeek, Pornhub makes up one of several pornographic websites in the company's "Pornhub Network", alongside YouPorn, RedTube, and others. In 2013, Thylmann sold his stake in the company to senior management, Feras Antoon and David Tassillo. In March 2010, the company was purchased by Fabian Thylmann as part of the Manwin conglomerate, now known as MindGeek. Pornhub was founded by web developer Matt Keezer as a website within the company Interhub, and launched on. ![]() A 2023 documentary, Money Shot: The Pornhub Story, covers the opposition to Pornhub and the views of some pornographic performers. This reduced the content from 13 million to 4 million videos. On 14 December 2020, Pornhub removed all videos by unverified users. In December 2020, following a New York Times exposé on such content (and its associated potential backlash), payment processors Mastercard and Visa cut their services to Pornhub. The company has been criticized for slow or inadequate responses to some of these incidents, including the hosting of the high-profile channel GirlsDoPorn, which was closed in 2019, following a lawsuit and charges of sex trafficking. Incidents have been reported of Pornhub hosting non-consensual pornography. It offers virtual reality porn, amongst other products, and hosts the Pornhub Awards annually. The site is available internationally, but has been blocked by several individual countries (such as India, mainland China, the Philippines, Pakistan and Sri Lanka). In March 2010, the company was bought by MindGeek (known then as Manwin), which owns numerous other pornographic websites. ![]() Pornhub also has an office and servers in Limassol, Cyprus. ![]() Pornhub was launched in Montreal, Canada, in 2007. As of November 2022, Pornhub is the 13th-most-trafficked website in the world and the second-most-trafficked adult website after XVideos. It is one of several pornographic video-streaming websites owned by MindGeek. Pornhub is a Canadian-owned internet pornography website. |
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